血清同型半胱氨酸和B型脑钠肽水平在评估PCI术后左心功能中的应用价值

The Value of the Application of Serum Homocysteine and B-type Brain Natriuretic Peptide Levels in the Assessment of Left Heart Function after PCI

目的:分析血清同型半胱氨酸(Hcy)、B型脑钠肽(BNP)水平在经皮冠状动脉介入术(PCI)后左心功能中的应用价值。方法:选取2022年1月-2022年8月惠州市博罗县人民医院收治的冠心病患者92例为观察对象,根据患者纽约心脏病协会心功能分级进行分组,对照组心功能Ⅰ~Ⅱ级,共52例,观察组心功能Ⅲ~Ⅳ级,共40例。患者均接受PCI手术治疗,比较两组患者血清学指标、手术前后心功能水平,采用线性回归分析Hcy、BNP水平与术后左心功能的关系。结果:术后,两组患者Hcy和BNP水平均降低,对照组低于观察组,差异有统计学意义(P<0.05);术后,两组患者左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)水平均降低,左室射血分数(LVEF)、A/E水平均升高,观察组LVEDD、LVESD、LVEF水平高于对照组,A/E水平低于对照组,差异有统计学意义(P<0.05);PCI术后患者的Hcy、BNP水平与患者LVEDD、LVESD、LVEF呈负相关,与A/E水平呈正相关(P<0.05)。结论:PCI术后患者的Hcy、BNP水平与患者LVEDD、LVESD、LVEF呈负相关,与A/E水平呈正相关,术后患者Hcy、BNP水平越低,患者心功能恢复越好,因此PCI患者预后评估可参考Hcy、BNP水平变化。

Objective:To analyze the value of serum homocysteine(Hcy)and B-type brain natriuretic peptide(BNP)levels in left heart function after percutaneous coronary intervention(PCI).Methods:92 patients with coronary heart disease admitted to Boluo County People's Hospital from January 2022 to August 2022 were selected as observation subjects.Patients were grouped according to the New York Heart Association cardiac function classification,with 52 cases in the control group with cardiac function gradeⅠ~Ⅱand 40 cases in the observation group with cardiac function gradeⅢ~Ⅳ.Patients were treated with PCI procedure.The serological indexes,pre-and post-operative cardiac function levels of the two groups were compared,and the relationship between Hcy and BNP levels and postoperative left heart function was analyzed by linear regression.Results:After surgery,Hcy and BNP levels were reduced in both groups,and the control group was lower than the observation group,the difference was statistically significant(P<0.05).After surgery,the levels of left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)were decreased,and the levels of left ventricular ejection fraction(LVEF)and A/E were increased in both groups.The levels of LVEDD,LVESD,and LVEF in the observation group were higher than those in the control group,and the levels of A/E were lower than those in the control group,with statistically significant differences(P<0.05).The levels of Hcy and BNP in patients after PCI were negatively correlated with patients'LVEDD,LVESD,and LVEF,and positively correlated with the levels of A/E(P<0.05).Conclusion:Hcy and BNP levels of patients after PCI were negatively correlated with patients'LVEDD,LVESD,and LVEF,and positively correlated with A/E levels,and the lower the Hcy and BNP levels of patients after PCI,the better the patients'cardiac function recovery,so the prognosis assessment of PCI patients can refer to the changes of Hcy and BNP levels.