精索静脉曲张对睾丸生精功能影响的研究进展

Advance of varicocele on testicular spermatogenesis

精索静脉曲张(varicocele, VC)是男性泌尿生殖系统的常见疾病之一,其发病率以青壮年较高,其中80%~98%好发于左侧精索静脉。研究发现,VC能够影响睾丸局部微环境的温度、参与生精环境局部的氧化应激进程、影响精子线粒体功能、调节男性内分泌系统过程、诱导睾丸及附睾细胞凋亡等。因此,VC会对男性睾丸生精功能造成重要影响,进而引发男性不育。但VC影响男性生精功能的具体分子机制尚未完全研究清楚。因此该文将对VC对睾丸生精功能影响的作用及机制研究作一综述。

Varicocele(VC) is one of the common diseases of the male genitourinary system, and its incidence is higher in young adults. Among them, 80%-98% of VC are more likely to occur in the left spermatic vein. Previous research has found that VC could affect the temperature of the local microenvironment of the testis, oxidative stress process in the spermatogenic environment, mitochondrial function of sperm, endocrine system, and apoptosis of testes and epididymal cells. Therefore, VC will have an important impact on spermatogenic process of the testicles to cause male infertility.However, the specific molecular mechanism of VC affecting male spermatogenesis has not been fully studied. Therefore,this article will review the effect and mechanism of VC on testicular spermatogenesis.