β-环糊精主客体识别抗菌剂及抗菌性能研究进展

Research progress on the host-guest recognition and antibacterial performance of β-cyclodextrin with antibacterial agents

细菌污染与人类的生存息息相关,随着多重耐药细菌的增加,提高抗菌剂抗菌性能、抑制细菌传播和感染成为抗菌剂研究领域的热点问题。利用β-环糊精的包结作用与抗菌剂主客体识别改善抗菌剂的理化性质,增强抗菌剂的抗菌性能引起了广泛关注。环糊精具有内疏水外亲水的特殊结构,疏水内腔可选择性地与空腔大小相匹配的疏水客体分子进行主客体识别,将抗菌剂包合,从而改善抗菌剂理化性质,提高抗菌剂抗菌性能。本文综述了β-环糊精及其衍生物与有机抗菌剂、天然抗菌剂主客体识别对抗菌剂理化性质及抗菌性能的影响,分析了主客体识别的包合机理及主客体之间的作用,系统地归纳总结了环糊精主客体识别抗菌剂对不同细菌的抗菌作用及在医药、纺织、食品等领域的应用研究现状,以期为环糊精主客体识别抗菌剂的深入研究及应用提供参考。

Bacterial contamination is closely related to human survival.With the increase of multidrug-resistant bacteria,improvement of antibacterial performance of antibacterial agents and inhibition of bacterial spread,infection have become hot issues in the field of antimicrobial research.The inclusion effect of the host-guest recognition ofβ-cyclodextrin with antibacterial agents can enhance the physicochemical properties and antimicrobial performance of antibacterial agents and has attracted much attention.β-Cyclodextrin has a special structure with internal hydrophobicity and external hydrophily,and the hydrophobic cavity can selectively recognize and encapsulate hydrophobic guest molecules antimicrobial agents matching cavity size to improve the physicochemical properties of antibacterial agents.This review summarizes the effects of host-guest recognition ofβ-cyclodextrin and its derivatives with organic and natural antimicrobial agents on physicochemical and antimicrobial properties,analyzes the inclusion mechanism of host-guest recognition and the role between the host and the guest,thus systematically summarizes antibacterial effect of the inclusion complex on different bacteria and current research status in medicine,textile,food and other fields to provide a reference for the further research and application of host-guest recognition of cyclodextrin with antibacterial agents.