基于数据挖掘探析《重订古今名医临证金鉴·不孕卷》中不孕症的用药规律

Medication rule of infertility in Revised Clinical Practice Experience of Famous Ancient and Modern Doctors:Volume of Infertility:An analysis based on data mining

目的:基于数据挖掘分析《重订古今名医临证金鉴·不孕卷》中不孕症的用药规律。方法:遴选并整理《重订古今名医临证金鉴·不孕卷》中治疗不孕症的有效经验方,对药物进行频数分析,采用SPSS Modeler 18.0统计软件进行关联规则分析,采用SPSS 28.0软件进行因子分析、聚类分析。结果:共收录59位古今名医治疗不孕症的方剂222首,中药238味,总用药频次为2511次,排前5位的中药依次为当归、白芍、川芎、香附、熟地黄。排前5位的功效种类依次为补虚药、活血化瘀药、理气药、清热药及利水渗湿药。中药药性以温为主,其次为平、寒性;药味以甘为主,其次为辛、苦味;归经以肝、脾、肾、心经为主。关联规则分析出高频关联药对16条,中药因子分析出6个公因子,聚类分析出5个聚类方。结论:《重订古今名医临证金鉴·不孕卷》所载历代医家治疗不孕症多以活血化瘀、补肾养血、疏肝行气、燥湿化痰为法,尤其重视从血论治,常以四物汤为基础方,为后世医家治疗不孕症提供了借鉴。

Objective:To investigate the medication rule of infertility in Revised Clinical Practice Experience of Famous Ancient and Modern Doctors:Volume of Infertility based on data mining.Methods:Effective experienced prescriptions for the treatment of infertility were selected from Revised Clinical Practice Experience of Famous Ancient and Modern Doctors:Volume of Infertility,and drug frequency was analyzed.SPSS Modeler 18.0 was used for association rule analysis,and SPSS 28.0 was used for factor analysis and cluster analysis.Results:A total of 222 prescriptions used by 59 famous ancient and modern doctors for the treatment of infertility were collected,involving 238 traditional Chinese medicine(TCM)drugs.Total drug frequency was 2511 times,and the top 5 TCM drugs were Angelica sinensis,Radix Paeoniae Alba,Rhizoma Chuanxiong,Rhizoma Cyperi,and prepared Radix Rehmanniae.The top 5 types of TCM drugs in terms of function were deficiency-tonifying drugs,blood-activating and stasis-resolving drugs,Qi-regulating drugs,heat-clearing drugs,and diuresis-inducing and dampness-draining drugs.TCM drugs with a warm nature accounted for the highest proportion,followed by those with a neutral or cold nature;drugs with a sweet taste accounted for the highest proportion,followed by those with a pungent or bitter taste;most drugs entered the liver,spleen,kidney,and heart meridians.The association rule analysis obtained 16 high-frequency drug combinations,the TCM factor analysis obtained 6 common factors,and the cluster analysis obtained 5 cluster prescriptions.Conclusion:The famous ancient and modern doctors recorded in Revised Clinical Practice Experience of Famous Ancient and Modern Doctors:Volume of Infertility mainly used the methods of blood-activating and stasis-resolving therapy,kidney-tonifying and blood-nourishing therapy,liver-soothing and Qi-moving therapy,and dampness-drying and phlegm-eliminating therapy for the treatment of infertility,especially by solving disorders of the blood system,and Siwu Decoction was often used as the basic prescription,which provides a reference for the treatment of infertility by doctors of later generations.