E-钙黏素和N-钙黏素在胃肠道间质瘤中的表达及其临床意义

Expression of E-cadherin and N-cadherin in Gastrointestinal Stromal Tumors and Their Clinical Significance

目的探讨胃肠道间质瘤(GISTs)中E-钙黏素(E-cad)和N-钙黏素(N-cad)的表达及其临床意义。方法应用免疫组化SP法检测216例GISTs中E-cad和N-cad的表达情况,分析二者与胃肠道间质瘤临床病理参数的关系。结果GISTs中E-cad阳性表达率为59.26%,N-cad阳性表达率为76.39%,E-cad和N-cad表达与GISTs的发生年龄、性别、部位、组织学类型无关,而与GISTs的病理分级和是否远处转移有关(P<0.05),且E-cad和N-cad的表达呈显著性负相关。结论E-cad和N-cad联合检测可作为判定GISTs恶性程度及预后的参考指标。

Objective To investigate the expression of E-cadherin and N-cadherin in gastrointestinal stromal tumors and their clinical significance.Method The SP immunohistochemistry was used to detect the expression of E-cadherin and N-cadherin in 216 cases with GISTs.The relationship between them and clinic pathological factors with gastrointestinal stromal tumor was analyzed.Results The positive expression rate of E-cadherin was 59.26%,and the positive expression rate of N-cadherin was 76.39%.The ex-pression of E-cad and N-cad was not related to the age,sex,location and histological type of GISTs,but was closely correlated with the pathological grade of GISTs and tumor metastasis(P<0.05).There was significant negative correlation between E-cad and N cad expression.Conclusion The combined detection of E-cad and N-cad can be used as a reference to determine the malignant de-gree and prognosis of GISTs.