胆囊癌临床治疗的现状与展望

Current situation and prospect in the clinical treatment of gallbladder cancer

胆囊癌预后差,缺乏有效的综合治疗手段,外科治疗是该病最主要的治疗方法。术前精准评估和充分准备,以及术中安全、有效、规范切除肿瘤是治疗成功的关键。重视意外胆囊癌的防范和合理治疗。新辅助或转化治疗能充分发挥化疗、靶向、免疫药物对肿瘤细胞的杀伤作用,达到术前降期或转化目的,提高胆囊癌根治性切除率,改善患者预后。

Gallbladder carcinoma is a tumor with poor prognosis and lack of effective comprehensive treatment.At present,surgical resection is still the main treatment for gallbladder carcinoma.Precise evaluation and adequate preparation before surgery,and safe,effective,standar-dized resection are the key points to successful treatment of gallbladder carcinoma.In clinic,there has been a growing appreciation of the prevention and reasonable treatment of incidental gallbladder carcinoma.Neoadjuvant and conversion therapy give full play to the effects of chemotherapy,targeted therapy,and immunotherapy agents on tumor cells,which can achieve the goal of downstage or conversion of tumors before surgery,increasing the radical resection rate,and improving the prognosis of patients.