摘要
冠心病是一种严重威胁人类健康且发病率较高的疾病,血瘀证是其最主要证型,研究发现肠道微生态和DNA甲基化均与冠心病血瘀证发生有关,且肠道微生态和表观遗传修饰相互影响,肠道微生态失调可能调控宿主表观遗传修饰导致疾病的发生;反之表观遗传层面的变化也影响到肠道微生物稳态。中医“心与小肠相表里”理论与现代“肠道菌群失衡可能促发冠心病”相似,且中医证候与DNA甲基化关系紧密。文章论述了肠道微生态与DNA甲基化对话对冠心病血瘀证的影响,以及中药干预冠心病血瘀证相关基因甲基化修饰和调节肠道菌群的研究动态,为找到冠心病的肠道微生态和基因表达及中药调控的结合点提供参考价值,为中医药早期防治冠心病提供重要意义的理论和依据。
Coronary heart disease(CHD) is a serious threat to human health and has a high morbidity,and blood stasis syndrome is the most important syndrome type. Studies have found that both intestinal microecology and DNA methylation are related to the occurrence of CHD with blood stasis syndrome,and intestinal microecology and epigenetic modifications interact with each other. Intestinal dysbiosis may regulate the epigenetic modifications of the host leading to the occurrence of disease.On the contrary,epigenetic changes also affect intestinal microbial homeostasis. The theory of ‘exterior interior relationship between heart and small intestine’ in traditional Chinese medicine(TCM) is similar to the modern theory that ‘the imbalance of intestinal flora may promote coronary heart disease’,and there is a close relationship between TCM syndromes and DNA methylation. Therefore,this article discusses the influence of intestinal microecology and DNA methylation on CHD and blood stasis syndrome,as well as the research trends of Chinese herbs intervention in CHD with blood stasis syndrome related gene methylation modification and regulation of intestinal flora,in order to provide reference value for finding the combination of intestinal microecology and gene expression of CHD with Chinese medicine regulation. It provides an important theory and basis for the early prevention and treatment of CHD with TCM.
作者
张书萌
陈伶利
于子璇
陈宇霞
肖清玄
罗佳敏
陈杏
李杰
ZHANG Shu-meng;CHEN Ling-li;YU Zi-xuan;CHEN Yu-xia;XIAO Qing-xuan;LUO Jia-min;CHEN Xing;LI Jie(Hunan University of Chinese Medicine,Changsha 410208,China;Provincial Key Laboratory of TCM Diagnostics,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Key Laboratory of Pathogenic Biology Based on Integrated Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2023年第2期722-726,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81874375)
湖南省自然科学基金项目(No.2022JJ30430)
湖南省教育厅科学研究重点项目(No.21A0231)。
关键词
冠心病
血瘀证
肠道微生态
DNA甲基化
中药干预
Coronary heart disease(CHD)
Blood stasis syndrome
Intestinal microecology
DNA methylation
Chinese herbs intervention