安寐颗粒对失眠伴高血压虚证型患者睡眠质量及血压昼夜节律的影响

Effects of Anmei Granules on sleep quality and blood pressure circadian rhythm in insomnia with hypertension patients with deficiency syndrome

目的:探讨安寐颗粒治疗失眠伴高血压虚证型患者睡眠质量及血压昼夜节律的影响,评价其临床疗效。方法:将120例患者随机分为观察组和对照组,每组60例,两组患者均给予睡眠卫生宣教和降压基础治疗,观察组口服安寐颗粒,对照组口服模拟剂,疗程为4周;比较两组患者治疗前后匹兹堡睡眠质量指数(PSQI)评分、SPIEGEL量表、晨峰血压及血压变异性的差异,并记录不良反应,进行临床疗效判定。结果:观察组脱落3例,完成观察57例;对照组脱落8例,完成观察52例。观察组治疗失眠的总有效率(89.47%,51/57)显著高于对照组(21.15%,11/52)(P<0.05);观察组治疗后PSQI评分和SPIEGEL量表评分较治疗前显著降低(P<0.05),且低于对照组(P<0.05);两组患者治疗后晨峰血压较治疗前均显著降低(P<0.05)。结论:安寐颗粒能有效改善失眠伴高血压虚证型患者睡眠质量,而对血压昼夜节律无明显影响。

Objective:To investigate the effects of Anmei Granules on sleep quality and circadian rhythm of blood pressure in insomnia with hypertension patients with deficiency sydrome and to evaluate its clinical efficacy.Methods:A total of 120 patients were randomly divided into the observation group and the control group,60 patients in each group.Both groups were given sleep hygiene education and basic antihypertensive treatment,and the observation group was given Anmei Granules orally while the control group was given placebo orally for 4 weeks.The differences in PSQI score,SPIEGEL scale,morning peak blood pressure and blood pressure variability between the two groups before and after treatment were compared,and adverse effects were recorded.Clinical efficacy was determined.Results:In the observation group,there were 3 cases of shedding and 57 cases of completion of observation;in the control group,there were 8 cases of shedding and 52 cases of completion of observation.The overall effective rate of treatment for insomnia was higher in the observation group(89.47%,51/57)than in the control group(21.15%,11/52)(P<0.05).The PSQI score and the SPIEGEL scale score decreased in the observation group after treatment compared with those before treatment(P<0.05),and decreased compared with those after treatment(P<0.05).The morning peak blood pressure decreased after treatment in both groups compared with that before treatment(P<0.05).Conclusion:Anmei Granules can effectively improve the sleep quality of patients with insomnia with hypertension in the deficiency syndrome,without any significant effect on the circadian rhythm of blood pressure.