雷公藤多苷联合醋酸泼尼松治疗肾病综合征患者的效果

Effects of Tripterygium glycosides combined with Prednisone acetate in treatment of nephrotic syndrome

目的:观察雷公藤多苷联合醋酸泼尼松治疗肾病综合征患者的效果。方法:选取2020年1月至2021年12月该院收治的86例肾病综合征患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各43例。对照组给予醋酸泼尼松片治疗,观察组在对照组基础上联合雷公藤多苷片治疗,比较两组疗效、血脂指标[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)]水平、肾功能指标[血清尿素氮(BUN)、血肌酐(Scr)、尿肾损伤分子1(KIM-1)]水平、血清白细胞介素-18(IL-18)水平和不良反应发生率。结果:观察组治疗总有效率为95.35%,明显高于对照组的81.40%,差异有统计学意义(P<0.05);治疗6个月后,观察组TG、TC、LDL-C、BUN、Scr、KIM-1和IL-18水平均低于对照组,差异有统计学意义(P<0.05);治疗期间,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:雷公藤多苷联合醋酸泼尼松治疗肾病综合征患者可提高治疗总有效率,降低血脂指标、肾功能指标水平和IL-18水平,效果优于单纯醋酸泼尼松治疗。

Objective: To observe effects of Tripterygium glycosides combined with Prednisone acetate in treatment of nephrotic syndrome.Methods: A prospective study was conducted on 86 patients with nephrotic syndrome admitted to this hospital from January 2020 to December 2021.They were divided into observation group and control group according to the random number table method, 43 cases in each. The control group was treated with Prednisone acetate tablets, while the observation group was treated with Tripterygium glycosides tablets on the basis of that of the control group. The efficacy, the blood lipid index levels [triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C)], the renal function index levels [serum urea nitrogen(BUN), serum creatinine(Scr), urine kidney injury molecule 1(KIM-1)], the serum interleukin-18(IL-18)level, and the incidence of adverse reactions were compared between the two groups. Results: The total effective rate of treatment in the observation group was 95.35%, which was significantly higher than 81.40% in the control group, and the difference was statistically significant(P<0.05). After 6 months of treatment, the levels of TG, TC, LDL-C, BUN, Scr, KIM-1 and IL-18 in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). During the treatment, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions: Tripterygium glycosides combined with Prednisone acetate in the treatment of nephrotic syndrome can improve the total effective rate of treatment, and reduce the levels of blood lipid indexes, renal function indexes and IL-18. Moreover, it is superior to single Prednisone acetate treatment.