益肾健骨汤联合常规西药治疗骨质疏松性胸腰椎压缩骨折术后患者的效果

Effects of Yishen Jiangu decoction on postoperative patients with osteoporotic thoracolumbar vertebral compression fractures

目的:观察益肾健骨汤联合常规西药治疗骨质疏松性胸腰椎压缩骨折(OTCF)术后患者的效果。方法:选取2018年3月至2021年3月该院收治的90例OTCF患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各45例。两组均行PVP术治疗,在此基础上,对照组给予阿仑膦酸钠和碳酸钙D3治疗,观察组在对照组基础上联合益肾健骨汤治疗,比较两组临床疗效、治疗前后骨密度和腰椎功能[日本骨科协会腰痛评价表(JOA)]评分、骨代谢指标[骨钙素(BGP)、Ⅰ型前胶原羟基端肽(PICP)、骨碱性磷酸酶(BALP)]水平及不良反应发生率。结果:观察组治疗总有效率为95.56%,高于对照组的82.22%,差异有统计学意义(P<0.05);观察组骨密度和JOA评分均高于对照组,差异有统计学意义(P<0.05);观察组BGP、PICP、BALP水平均高于对照组,差异有统计学意义(P<0.05);两组治疗期间均未见明显不良反应。结论:在阿仑膦酸钠联合碳酸钙D3治疗基础上采用益肾健骨汤治疗OTCF术后患者,提高治疗总有效率、骨密度水平、骨代谢指标水平和JOA评分的效果优于单纯阿仑膦酸钠联合碳酸钙D3治疗。

Objective:To observe effects of Yishen Jiangu decoction with conventional western medicine on postoperative patients with osteoporotic thoracolumbar vertebral compression fractures(OTCF).Methods:A prospective study was conducted on 90 OTCF patients admitted to the hospital from March 2018 to March 2021.They were divided into control group and observation group according to the random number table method,45 cases in each.Both groups were treated with PVP.On this basis,the control group was treated with Alendronate sodium and Calcium carbonate D3,while the observation group was treated with Yishen Jiangu decoction on the basis of that of the control group.The clinical efficacy,the bone mineral densities before and after the treatment,the lumbar function[Japanese Orthopaedic Association back pain evaluation scale(JOA)]score,the bone metabolism index levels[osteocalcin(BGP),type I procollagen carboxyl-terminal peptide(PICP),bone alkaline phosphatase(BALP)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was95.56%,which was higher than 82.22%in the control group,and the difference was statistically significant(P<0.05).The bone mineral density and the JOA score of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).The levels of BGP,PICP and BALP in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there were no obvious adverse reactions in the two groups during the treatment.Conclusions:On the basis of Alendronate sodium combined with Calcium carbonate D3,Yishen Jiangu decoction can improve the total effective rate,the bone mineral density,the bone metabolism index levels and the JOA score of the postoperative patients with OTCF.Moreover,it is superior to single Alendronate sodium combined with Calcium carbonate D3treatment.