自噬调节策略在炎症性肠病临床前研究中的进展

Autophagy-regulated strategies in pre-clinical studies of inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一种难治性肠道炎症性疾病,包括溃疡性结肠炎和克罗恩病,具有进行性且不可预测的病程特点。肠道炎症和免疫反应异常与IBD发病机制密切相关。自噬是细胞中重要的分解代谢过程,已被证明与包括IBD在内的多种炎症性疾病存在联系。本文从自噬功能障碍与IBD的关系出发,重点阐述了炎症小体抑制剂、肠道微生物群调节剂及其他信号调节剂等作用于肠上皮细胞和巨噬细胞的自噬调节剂在IBD中的研究进展。

Inflammatory bowel disease(IBD)is a group of chronic idiopathic colorectal inflammatory diseases with a progressive and unpredictable course,including ulcerative colitis(UC)and Crohn’s disease(CD).Abnormal intestinal inflammation and immune response contribute to the pathogenesis of IBD.Autophagy as an essential catabolic process in cells,has been demonstrated to have associations with a variety of inflammatory diseases including IBD.Here,we review the relationship between autophagy dysfunction and the process of IBD.The progress of several autophagy regulators for intestinal epithelial cells and macrophages is highlighted(inflammasome inhibitors,intestinal flora regulators,and other signal regulators)in the current studies on IBD.