聚合物自愈合机制及在生物医药领域的应用研究进展

Research progress of polymer self-healing mechanism and its application in biomedicine

聚合物自愈合主要依据聚合物的分子结构及其相互作用,部分需给予外部刺激,如光、热、pH等。近年来诸多研究发现聚合物的自愈合特性可延长材料的寿命,同时在愈合后仍保持着聚合物的机械性能。根据聚合物材料的作用方式不同,分为自主自愈合和非自主自愈合。其中自主自愈合主要通过可逆的共价键(席夫碱键、狄尔斯-阿尔德反应、酰肼键)、可逆非共价键(氢键、金属-配体配位键、静电相互作用、π-π堆积、疏水相互作用)或二者结合发挥作用。具有独特的自愈合特性的药物载体在生物大分子的封装和稳定释放方面起着重要作用。本综述根据聚合物的自愈合机制及其在生物医药领域中的应用进行了简要的总结讨论。

Polymer self-healing is mainly based on the molecular structure and interaction of polymers,and some need external stimulation,such as light,heat,pH,etc.In recent years,many studies have found that the selfhealing properties of polymers can prolong the life of materials,while maintaining the mechanical properties of polymers after healing.According to the different action modes of polymer materials,it can be divided into autonomous self-healing and non-autonomous self-healing.Among them,autonomous self-healing mainly works through reversible covalent bonds(Schiff base bond,Diels-Alder reaction,hydrazide bond),reversible non-covalent bonds(hydrogen bond,metal-ligand coordination bond,electrostatic interaction,π-πstacking interaction,hydrophobic interaction)and a combination of the two interactions.Drug carriers with unique self-healing properties play an important role in the encapsulation and stable release of biomacromolecules.In this review,the self-healing mechanism of polymers and their applications in the field of biomedicine were briefly summarized and discussed.