摘要
An N-heterocyclic carbene(NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linearβ-aminoenone products.Theβ-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions.The reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.
基金
the financial support from the National Natural Science Foundation of China(Nos.21772029,32172459,21961006,22001173)
The 10 Talent Plan(Shicengci)of Guizhou Province(No.[2016]5649)
the Science and Technology Department of Guizhou Province(Nos.[2019]1020,Qiankehejichu-ZK[2021]Key033)
the Program of Introducing Talents of Discipline to Universities of China(111 Program,No.D20023)at Guizhou University
Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[No.Qianjiaohe KY(2020)004]
the Guizhou Province First-Class Disciplines Project(No.GNYL(2017)008)
Guizhou University(China)。
