肠道微生物与骨质疏松相关性的研究进展

Advances in the relationship between gut microbiota and osteoporosis

随着人口老龄化问题的加剧,骨质疏松症的高发生率降低了人们的生活质量。越来越多的证据表明,肠道微生物群与骨代谢联系密切,肠道微生物群稳态的破坏会导致宿主的病理生理反应,从而引起骨质疏松。通过研究两者之间的相互作用,或许能为骨质疏松症的预防及相关诊疗提供有价值的帮助。本文就目前肠道微生物与骨质疏松症相关机制和主要治疗的研究现状作一综述。

The high incidence of osteoporosis in the aging population reduces the quality of life.There is growing evidence that the gut microbiota is closely linked to bone metabolism.Gut microbiota disorder will lead to pathophysiological responses in the host,which can cause osteoporosis.The research on the interactions between gut microbiota and osteoporosis may contribute to the management of osteoporosis-related conditions.This paper reviews the advances in the interactions between gut microbiota and osteoporosis and the relevant therapies.