结直肠癌实验室生物标志物研究进展

Research progress of laboratory biomarker for colorectal cancer

结直肠癌是严重威胁人类生命和健康的重大公共医疗卫生问题。实验室检测结果是临床医生对结直肠癌诊疗决策的主要依据之一。随着人们对结直肠癌诊断、治疗和预后需求的不断提高,各种早期诊断结直肠癌的实验室生物标志物不断被发掘。本文通过对结直肠癌的实验室早期诊断生物标志物进行阐述,为临床合理选用实验室生物标志物、进一步提高结直肠癌筛查、辅助诊断、疗效监测和预后评估的准确性和可靠性提供参考依据。

Colorectal cancer(CRC)has become a major medical and public health threat to human life and health.At present,the clinical diagnosis and treatment of CRC mainly depends on the laboratory tests.With the increasing demand for treatment and prognosis,screening methods for CRC are emerging.In order to provide a reference for reasonable selection of laboratory diagnostic biomarkers,and further improve the accuracy and reliability of colorectal cancer screening,auxiliary diagnosis,efficacy monitoring,as well as prognostic evaluation,this article reviews the laboratory screening and diagnostic methods for CRC,and makes outlook for the future detection markers of CRC.