摘要
类器官是具有三维结构、高度保留来源组织器官特性的体外3D类组织培养物.类器官的兴起和发展为临床医学提供了一项重要的工具.患者源性类器官可以作为模拟和研究疾病模型,帮助临床医生更好地理解相关疾病病理生理,并制定相应的治疗策略;肿瘤患者类器官可以为药物筛选提供更准确的平台,帮助和指导临床医生为癌症患者选择最合适的治疗方案,提高患者临床预后.本文将介绍类器官在临床医学中的应用和研究进展.
Three-dimensional cultured organoids recapitulate histopathologic and molecular characteristics of the primary tissues.The rise and development of organoids provide an important platform for clinical medicine research.Patient-derived organoids could be used as models to help clinicians to better understand the pathophysiology of related diseases and formulate corresponding treatment strategies;Organoids derived from tumors could be utilized as a drug screening system for precision medicine,helping clinicians to select the most appropriate regimen for cancer patients and to improve the clinical outcome.This review would summarize the application and research advances of organoids in clinical medicine.
作者
莫少波
管若羽
张龙
蔡三军
彭俊杰
华国强
MO ShaoBo;GUAN RuoYu;ZHANG Long;CAI SanJun;PENG JunJie;HUA GuoQiang(Department of Colorectal Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China;Instituteof Radiation Medicine,FudanUniversity,Shanghai 200032,China;Cancer institute,Fudan University Shanghai Cancer Center,Shanghai 200032,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2023年第2期221-237,共17页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:31470826,31670858,U1932145)
上海市科学技术委员会科研计划(批准号:18401933402)资助。
关键词
类器官
临床医学
应用
研究进展
organoid
clinical medicine
application
research advances
