2012年至2020年重庆地区居民肝癌死亡率及疾病负担变化趋势

Trend of mortality and disease burden of liver cancer from 2012 to 2020 in Chongqing

目的:了解2012年至2020年重庆地区居民肝癌死亡率及疾病负担变化趋势。方法:肝癌死亡个案病例资料(ICD-10:C22)来源于重庆市全人群死因监测报告数据库。采用SPSS 26.0统计分析死亡率、标化死亡率、早死所致的寿命损失年(years of life lost, YLL)和平均减寿年数(average years of life lost, AYLL)等指标,不同性别与地区间死亡率比较用χ^(2)检验,趋势分析采用年度变化百分比(annual percentage change, APC)表示。结果:2012年重庆市肝癌死亡率与标化死亡率分别为29.87/10万与20.27/10万,2020年重庆市肝癌死亡率与标化死亡率分别为31.21/10万与18.16/10万,死亡率与标化死亡率APC分别为0.39%与-0.83%,变化趋势均无统计学差异(P>0.05)。2012年至2020年男性历年肝癌死亡率均高于女性,差异均有统计学意义(P<0.01)。2012年至2020年农村地区历年肝癌死亡率均高于城市,差异均有统计学意义(P<0.01)。2012年重庆市肝癌导致的YLL率为8.72‰,2020年YLL率为8.02‰,APC为-1.28%,变化趋势无统计学差异(P>0.05),AYLL以年均1.66%的速度下降(P<0.05)。男性AYLL高于女性,分别以年均1.55%(P<0.05)和1.96%(P<0.05)的速度下降,城市AYLL低于农村AYLL,城市和农村AYLL总体上分别以年均1.59%(P<0.05)和1.72%(P<0.05)的速度下降。结论:重庆市肝癌死亡率较高,早死导致的疾病负担重,男性与农村地区居民是肝癌发生的重点人群。

Objective:To study the trend of mortality and disease burden of liver cancer from 2012 to 2020 in Chongqing.Methods:Case data of liver cancer deaths(ICD-10:C22) were obtained from the database of mortality surveillance report in Chongqing.SPSS 26.0 was used to statistically analyze the mortality rate, standardized mortality rate by Chinese standard population, years of life lost(YLL) and average years of life lost(AYLL).The χ^(2) test was used to analyze the difference between male and female, urban area and rural area.The annual percentage change(APC) was used to analyze the trend by t test.Results:The mortality rate and standardized mortality rate of liver cancer in Chongqing were 29.87/100 000 and 20.27/100 000 in 2012 and 31.21/100 000 and 18.16/100 000 in 2020,respectively and their APC were 0.39% and-0.83%,respectively, with no statistically significant trend(P>0.05).The mortality rate of liver cancer in males was higher than that of females in all calendar years from 2012 to 2020,and the difference was statistically significant(P<0.01).The mortality rate of liver cancer in rural areas was higher than that of urban areas in all calendar years from 2012 to 2020,and the difference was statistically significant(P<0.01).The YLL rate due to liver cancer in Chongqing was 8.72 per 1 000 in 2012 and 8.02 per 1 000 in 2020,with a YLL rate APC of-1.28%,with no statistically significant trend(P>0.05) and AYLL declining at an average annual rate of 1.66%(P<0.05).Male AYLL was higher than female, declining at an annual rate of 1.55%(P<0.05) and 1.96%(P<0.05) respectively, and urban AYLL was lower than rural AYLL,with urban and rural AYLL overall declining at an annual rate of 1.59%(P<0.05) and 1.72%(P<0.05).Conclusion:The mortality of liver cancer and the disease burden caused by early death in Chongqing are higher.Males and rural residents are the key groups of liver cancer.