玻璃体注射用万古霉素的应用与发展

Application and development of vancomycin for intravitreal injection

万古霉素是治疗感染性眼内炎最常用的糖肽类抗菌药物,然而由于眼球结构特殊,常规的眼部给药生物利用度往往极低(<5%)。而通过玻璃体腔注射药物,是目前解决这一难题的最好方式。最新的研究表明,纳米载体非常适合将亲水性或亲脂性药物递送至眼部组织,它可以克服眼部的多重屏障,延长药物在眼部组织中的驻留时间。纳米载体为万古霉素治疗感染性眼内炎提供了一种新的思路。本文综述了如何利用纳米载体提高药物在眼后段的渗透性和生物利用度,并阐明万古霉素纳米制剂在玻璃体内注射中的应用前景。

Vancomycin is a glycopeptide antibiotic commonly used for infectious endophthalmitis.However,the conventional ocular delivery strategies often have poor bioavailability(<5%)due to the particular structure of eyeball,and the consequent drug deliver showed barriers.At present,the best solution is intravitreal injection.Latest studies,showed nanocarriers could deliver hydrophilic or lipophilic drugs to the ocular tissues,prolong the retention time and enhance the bioavailability.Nanocarriers provide a new idea for the treatment of infectious endophthalmitis with vancomycin.This study reviewed the current research progress in the role of ocular nanoparticle delivery in improving the drug penetration and bioavailability to the posterior segment of the eye,and elucidated the prospect of vancomycin nanocarriers in intravitreal injection.