TRPV4在心血管疾病中作用的研究进展

Progress in role of TRPV4 in cardiovascular diseases

瞬时受体电位阳离子通道V亚家族成员4(transient receptor potential cation channel subfamily V member4,TRPV4)是瞬时受体电位阳离子通道(transient receptor potential cation channel, TRP)家族成员,是一种非选择性阳离子通道,对Ca^(2+)离子具有适中通透性,对Na^(+)和Mg^(2+)少量通透(PCa/PNa约为6~10,PCa/PMg约为2~3)。TRPV4在心血管系统表达广泛,主要表达于血管内皮细胞、血管平滑肌细胞、心肌细胞和成纤维细胞等,可调节血管张力和血管通透性,参与机械信号传导等。

Transient receptor potential cation channel subfamily V member 4(TRPV4) is a non-selective cation channel that is widely expressed in the cardiovascular system. Activation of TRPV4 induces an increase in intracellular calcium concentration and plays an important role in both physiological and pathological conditions. Recent studies have revealed that TRPV4 plays an important role in many pathophysiological processes closely related to cardiovascular diseases, including regulating vasodilation and protecting the integrity of the endothelial cell barrier, etc. This review discusses the evidence and its potential mechanisms of TRPV4 in diverse responses including hypertension, myocardial infarction, cardiac remodeling, congestive heart failure-induced pulmonary edema, atherosclerosis, and arrhythmia.