摘要
衰老生物学以健康老龄化为目标,主要围绕衰老生理性或病理性过程及机制开展研究。随着近年全球健康老龄化的战略部署,衰老生物学得以快速发展,2022年以来,全球在衰老研究政策支持、衰老研究模式拓宽、衰老标识拓展等方面取得了重要进展。鉴于此,该文重点从衰老生物学领域的总体发展态势、基础研究进展、临床研究进展等角度对2022年重要进展进行梳理分析,并对衰老生物学基础研究和临床研究未来重点发展方向以及发展模式进行展望,以期为后续研究提供参考。
Aiming at healthy aging,aging biology mainly focuses on the physiological or pathological processes and mechanisms of aging.With the strategy deployment of global healthy aging,aging biology has been developing rapidly in recent years.Since 2022,important progress has been made in the aspects of policy support for aging research,expansion of aging research models and acknowledgement of aging hallmarks around the world.In view of this,this paper focused on sorting out and analyzing important progress in 2022 from the perspectives of overall development trends,basic research progress and clinical research progress in the field of aging biology.Future development directions and models of basic and clinical research of aging biology were also prospected in order to provide references for subsequent research.
作者
张博文
范月蕾
陈大明
赵若春
毛开云
ZHANG Bo-Wen;FAN Yue-Lei;CHEN Da-Ming;ZHAO Ruo-Chun;MAO Kai-Yun(Shanghai Information Center for Life Sciences,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China)
出处
《生命科学》
CSCD
北大核心
2023年第1期33-41,共9页
Chinese Bulletin of Life Sciences
基金
中国科学院战略研究专项“生命与健康-重大创新领域战略规划研究(人口健康)”(GHJ-ZLZX-2021-08)
上海市2022年度“科技创新行动计划”软科学研究项目“国内外健康人群前瞻性队列建设情况调查研究”(22692117000)。
关键词
衰老生物学
微生态失调
巨自噬失活
队列研究
抗衰老干预
aging biology
dysbiosis
disabled macroautophagy
cohort studies
anti-aging interventions
