摘要
目的:研究卵巢上皮性肿瘤中岩藻糖基转移酶8(FUT8)表达水平并分析其临床意义。方法:利用免疫组织化学染色法对84例卵巢上皮性肿瘤进行病理学研究,包括上皮性卵巢癌71例,卵巢上皮性交界性肿瘤1例,卵巢上皮性良性肿瘤12例。结果:上皮性卵巢癌组织中FUT8表达水平显著高于卵巢上皮性良性肿瘤(P<0.05),浆液性卵巢癌FUT8表达显著高于粘液性卵巢癌(P<0.05),临床早期(I期)癌组织FUT8表达明显低于中晚期(II~IV期)(P<0.05)。结论:FUT8表达与卵巢上皮性肿瘤患者的良恶性、肿瘤类型及肿瘤分期有关。
Objective:To investigate fucosyltransferase-8 expression levels and analyze its clinical significance in ovarian epithelial tumors.Methods:A total of 84 ovarian epithelial tumors,including 71 epithelial ovarian carcinomas(experimental group),1 borderline ovarian tumor,and 12 benign ovarian epithelial tumors(control group),were examined using immunohistochemical staining.Results:FUT8 expression levels in epithelial ovarian cancer tissues were significantly higher than those in benign ovarian epithelial tumors(P<0.05).In epithelial ovarian cancer,fut8 expression was significantly higher in serous ovarian cancer than in mucinous ovarian cancer(P<0.05);FUT8 expression of ovarian cancer tissues in FIGO clinical early stage(stage I)was significantlylower than that in middle advanced stage(stages II to IV)(P<0.05).Conclusion:FUT8 expression is associated with benign and malignant,cancer type and tumor stage in patients with epithelial ovarian cancer.
作者
陈琳琳
徐茗
陈香楠
张大川
朱丽华
杨嫣君
叶文凤
Chen Linlin;Xu Ming;Chen Xiangnan;Zhang Dachuan;Zhu Lihua;YangYanjun;Ye Wenfeng(Department of Obstetrics and Gynecology,Taizhou Second People's Hospital of Jiangsu Province,Taizhou,Jiangsu 225511;Department of Obstetrics and Gynecology,The Third Affiliated Hospital of Soochow University,Changzhou,Jiangsu,213001;Department of Pathology,The Third Affiliated Hospital ofSoochow University,Changzhou,Jiangsu,213001;Department of Obstetrics and Gynecology,Shanghai Pudong New Area People's Hospital,Pudong,Shanghai,201299)
出处
《现代科学仪器》
2023年第1期70-74,共5页
Modern Scientific Instruments
基金
江苏省中医药科技发展计划项目(YB202055)
常州市应用基础研究计划(CJ20200110)
常州市科技计划应用基础研究指导性项目(CJ20219017)
浦东新区卫计委卫生计生科研项目资助(PW2002A-18)。
