miR-17-92基因簇在心血管疾病中的作用

Role of miR-17-92 Gene Cluster in Cardiovascular Diseases

我国心血管疾病负担沉重,严重威胁着人们的身心健康。研究证实,微小RNA(miRNA)在心血管疾病演变过程中扮演着重要角色。部分miRNA具有成簇聚集在染色体上的特点,其中miR-17-92基因簇是目前研究最为广泛的基因簇。本文归纳了近年来miR-17-92基因簇在心血管疾病中作用的相关研究,分析了miR-17-92基因簇各成员(miR-17、miR-18a、miR-19a、miR-19b、miR-20a、miR-92a)在动脉粥样硬化、心力衰竭、肺动脉高压、冠心病、心肌病病程进展中发挥的促进或抑制作用,并指出在今后的研究中需进一步明确miR-17-92基因簇各成员在心血管疾病中的相互协调作用机制,以便为临床治疗提供新靶点与新思路。

The burden of cardiovascular diseases in China is heavy,which seriously threatens people's physical and mental health.Research has confirmed that microRNA(miRNA)plays an important role in the evolution of cardiovascular diseases.Some miRNAs are characterized by clustering on chromosomes,among which miR-17-92 gene cluster is the most widely studied gene cluster at present.This paper summarizes the relevant research on the role of miR-17-92 gene cluster in cardiovascular disease in recent years,analyzes the promotion or inhibition role of each member of miR-17-92 gene cluster(miR-17,miR-18a,miR-19a,miR-19b,miR-20a,miR-92a)in the progression of atherosclerosis,heart failure,pulmonary hypertension,coronary heart disease,and cardiomyopathy,and points out that it is necessary to further clarify the coordination mechanism of each member of the miR-17-92 gene cluster in cardiovascular disease in future studies,so as to provide new targets and new ideas for clinical treatment.