面部色素增加性皮肤病外用处方数据库建立与用药规律挖掘

Establishment of external prescription database for facial pigmentation skin disease and mining of medication pattern

目的探讨治疗雀斑、黄褐斑外用方药用药规律。方法筛选古籍记载中医治雀斑、黄褐斑的外用方药,采用Excel数据记录系统,构建面部色素增加性皮肤病外用方数据库,通过对115首外用方剂进行频次分析、关联分析,总结治疗雀斑、黄褐斑常用外用中药、外用方法、基质及常用中药药对和药组。结果雀斑、黄褐斑虽病因不同,西医治疗方法各异,但古籍中外用中药大致相似,主要有白芷、白附子、白及、白蔹、茯苓等,常见药对和药组包括白丁香、白芷、白及、白附子、白蔹、甘松等,最常用的外用方法是擦面和洗面。选用最多的药物基质是鸡子白和蜜。结论经数据挖掘发现雀斑、黄褐斑的常用药物、基质药物、药对和外用方法,可为临床治疗及美容类产品提供思路。

Objective To explore the regularity of external-use Chinese medicine agents for curing freckle and chloasma Methods To screening the external prescriptions for freckles and chloasma recorded in ancient books.The Excel data recording system was used to build an external prescription database of Chinese medicines for facial pigmentation skin disease.The frequency analysis and correlation analysis of 115 external prescriptions were carried out to summarize the common herbs,external application method,matrix,common Chinese medicine pairs and drug groups in the treatment of freckle and chloasma.Results Although with different causes of disease and different western medicine methods for freckles and chloasma,the external prescriptions of Chinese medicine were similar in ancient literature,Mainly including Baizhi,Baifuzi,Baiji,Bailian and Fuling,etc.Common drug pairs and drug groups included Baidingxiang,Baizhi,Baiji,Baifuzi,Bailian and Gansong,etc.The most commonly external-used method was rubbing and cleansing,with chicken egg white and honey as most popular drug matrix.Conclusion Common drugs,matrix drugs,drug pairs and external application methods for freckles and chloasma found by data mining analysis can provide ideas and references for clinical treatment and developing beauty products.