不同功率密度1064 nm激光辐照下小鼠皮肤热损伤研究

Skin damage in mice induced by different power densities of 1064 nm laser

通过实验和理论分析研究1064 nm激光不同输出功率对小鼠皮肤的热损伤规律。利用皮肤镜与光学相干断层成像(OCT)评估小鼠皮肤组织热损伤程度;参考Arrhenius热损伤方程进行理论分析,并与实验结果对比。结果显示,当激光连续辐照时间为400 ms时,激光输出功率密度小于958 W/cm2时,激光辐照处泛红;激光输出功率密度为958~1160 W/cm2时,损伤呈白色水疱状;激光输出功率密度为1160~1370 W/cm2时,损伤呈浅坑状焦黄斑,损伤斑周围伴一圈鼓起的白色皮肤水疱;激光的功率密度在1370~2190 W/cm2,损伤呈红色坑状斑,损伤斑周围伴黑黄色焦痂。

The thermal damage of mouse skin under different output power of 1064 nm laser was studied by experiment and theoretical analysis.The degree of thermal injury of mouse skin tissue was evaluated by dermoscope and optical coherence tomography(OCT),and the theoretical analysis was made according to Arrhenius thermal damage equation,and the results were compared with the experimental results.The results show that when the laser’s continuous irradiation time is 400 ms and the laser output power density is less than 958 W/cm2,there is no obvious damage;when the laser output power density is 958-1160 W/cm2,the damage is white blister-like;when the laser output power density is 1160-1370 W/cm2,the damage is a shallow pit-like macula with a circle of bulging white skin blisters around the damage spot;when the laser power density is at 1370-2190 W/cm2,the damage is a red pit-like spot,and there is black-yellow eschar around the injury spot.