6-羟基染料木素与8-羟基染料木素的制备及生物活性研究进展

Progress in the Preparations and Bioactivities of 6-Hydroxygenistein and 8-Hydroxygenistein

6-羟基染料木素(6-OHG)和8-羟基染料木素(8-OHG)是染料木素A环上C6或C8位发生羟基化反应生成的衍生物,其分子中有更多酚羟基,同时含有邻二酚羟基结构,这也使它们的生物活性与染料木素相比发生了显著变化。研究表明,6-OHG和8-OHG具有抗氧化、抗诱变、抑制磷酸二酯酶3B活性、抗糖化、保肝、抗黑色素生成作用、改善记忆力等广泛的药理活性。本文将对6-OHG和8-OHG的来源、制备方法和生物活性研究进行综述,以期为两个化合物的开发利用提供参考。

6-hydroxygenistein(6-OHG)and 8-hydroxygenistein(8-OHG)are derivatives generated by hydroxylation at the C6 or C8 position on the A ring of genistein.They exhibited biological activities significantly different from those of genistein due to the increased number of phenolic hydroxyl groups and the existence of o-diphenol hydroxyl structure.Several studies have shown that 6-OHG and 8-OHG own a wide range of pharmacological activities such as antioxidant,antimutagenic,inhibition of phosphodiesterase 3B activity,antiglycation,hepatoprotective,antimelanogenic effects,and memory improvement etc.This article reviews the sources,preparation methods and biological activities of 6-OHG and 8-OHG,in order to provide references for the development and utilization of the two compounds.