慢性炎性脱髓鞘性多发性神经根神经病的研究进展

Research advances in chronic inflammatory demyelinating polyradiculoneuropathy

慢性炎性脱髓鞘性多发性神经根神经病(CIDP)是一种由细胞免疫和体液免疫共同介导的、累及周围神经系统的慢性自身免疫性疾病,常见临床表现为肢体无力和感觉障碍,电生理和病理检查以脱髓鞘为主要特征。CIDP的一线治疗包括糖皮质激素、静脉注射免疫球蛋白和血浆置换。部分患者对现有的免疫治疗效果差、预后不良。文中综述了近年来国内外在CIDP的发病机制、诊断和治疗方面取得的进展,旨在为CIDP的临床诊治提供参考。

Chronic inflammatory demyelinating polyradiculoneuropathy(CIDP)is a chronic autoimmune disease affecting the peripheral nervous system mediated by cellular and humoral immunity,characterized by limb weakness and sensory impairment.The main feature of CIDP by electrophysiological and pathological examinations is the demyelination of peripheral nerves.First-line treatment for CIDP includes glucocorticoids,intravenous immunoglobulins,and plasmapheresis.Some patients respond to current treatment not well and have a poor prognosis.Progress in the pathogenesis,diagnosis,and treatment of CIDP worldwide was reviewed in this article,aiming to provide references for the clinical diagnosis and treatment of CIDP.