基于数据挖掘的《普济方》痤疮外治方用药特色研究

Analysis on the medication rules of Pu Ji Fang for treating acne externally based on data mining

目的基于数据挖掘分析《普济方》痤疮外治用药特色。方法筛选《普济方》痤疮外治方并建立标准化数据库。采用古今医案云平台网页版分析药物频次、药物属性(药性、药味、归经),并对高频药物进行聚类分析。采用IBM SPSS Modeler 18.0软件对药物与药物、药物与剂型进行关联规则分析。结果共筛选出痤疮外治方87首,涉及药物164种,常用药物有白芷、川芎、白附子、铅粉等;药物药性以温、寒、平为主,药味以辛、甘、苦居多,归经以肺、脾、胃、肝经为主。关联性较强药对、药团为川芎-白芷、白附子-白芷-川芎。高频药物可聚为三类。高频剂型膏剂与药物猪脂、水银、铅粉关联性较强,高频剂型散剂与药物白芷、牵牛子、皂荚、藁本、川芎关联性较强。结论《普济方》痤疮外治以辛散发越为主,高频药物聚类分别针对体虚感邪证、外感风热证、血热郁滞证,提示了明代以前痤疮辨治特色,亦为现代临床诊疗提供了参考。

Objective To analyze the medication rules in the ancient book Pu Ji Fang for the external treatment of acne based on data mining method.Methods By screening out the methods of treating acne externally in Pu Ji Fang and establishing a standardized medical record database,this paper adopted the web version of Ancient and Modern Medical Record Cloud Platform to calculate the frequency,properties,flavors,and meridians of those medicines,and conduct cluster analysis by using IBM SPSS Modeler 18.0 software to analyze the association rules.Results A total of 87 prescriptions were selected,including 164 kinds of Chinese materia medica,among which.Radix Angelicae,Ligusticum Wallichii,Rhizoma Typhoni and lead powder are frequently appeared.The properties of those medicines are mainly warm,cold and mild;the flavors of those medicines are mainly spicy,acrid,sweet and bitter,and the meridians mainly belongs to lung,spleen,stomach and liver meridians.The medical pair and group with the strongest associationion are Ligusticum Wallichii-Radix Angelicae and Rhizoma Typhonii-Radix Angelicae-Ligusticum Wallichii.Those freuently appeared medicines could be grouped into three categories.The paste dosage that was frequently appeared has strong correlation with tallow,mercury and lead powder,while the powder dosage that was frequenctly appeared has strong correlation with Angelica Dahurica,Radix Saponicae,Gleditsia sinensis,Radices Ligustici Sinensis and Ligusticum Wallichii.Conclusions The application of data mining method could preliminarily reveal the medication rules of Pu Ji Fang for the external treatment of acne.The main treatment method is XinSanFaYue.The three categories of Chinese materia medica are used to treat the syndrome of asthenic habitus attacked by exogenous pathogenic factors,exterior attacked by wind heat and hot blood stasis respectively,showing the rules of treating acne externally before Ming Dynasty and providing references for the clinical treatment of acne.