叉头框蛋白C2、淋巴管内皮透明质酸受体-1的表达与皮肤鳞状细胞癌生物学特性的相关性

Correlation of the expressions of FoxC2 and LYVE-1 with biological characteristics of cutaneous squamous cell carcinoma

目的探讨叉头框蛋白C2(FoxC2)和淋巴管内皮透明质酸受体-1(LYVE-1)与皮肤鳞状细胞癌生物学特性的相关性。方法收集2013年10月至2021年1月在江苏大学附属医院收治的44例原发性皮肤鳞状细胞癌病人,采用免疫组织化学染色检测FoxC2、LYVE-1的表达情况,LYVE-1的表达情况用微淋巴管密度(MLVD)表示。结果FoxC2在皮肤鳞状细胞癌淋巴结转移组、中低分化组的高表达率[88.88%(8/9)、88.88%(16/18)]明显高于无淋巴结转移组、高分化组[42.85%(15/35)、26.92%(7/26)](均P<0.05)。LYVE-1在皮肤鳞状细胞癌淋巴结转移组、中低分化组的表达(13.31±6.23、14.28±4.42)明显高于无淋巴结转移组、高分化组(8.67±4.33、6.39±2.09)(均P<0.05)。FoxC2、LYVE-1的表达情况与病人的年龄、性别、肿瘤长径无关(均P>0.05)。FoxC2与LYVE-1的表达呈正相关(r=0.55,P<0.01)结论FoxC2及LYVE-1参与调控皮肤鳞状细胞癌生长及淋巴结转移,此结果为临床诊断及治疗皮肤鳞状细胞癌提供新的策略。

Objective To investigate the relationship between forkhead box protein C2(FoxC2) and lymphatic vessel endothelial receptor 1(LYVE-1) and the biological characteristics of cutaneous squamous cell carcinoma.Methods A total of 44 patients with primary skin squamous cell carcinoma admitted to The Affiliated Hospital of Jiangsu University in Zhenjiang, Jiangsu Province from October 2013 to January 2021 were collected. Immunohistochemical method was used to detect the expressions of FoxC2 and LYVE-1, and the expression of LYVE-1 was indicated by the microlymphatic vessel density(MLVD).Results The high expression rates of FoxC2 in the group with lymph node metastasis and the group with medium-low differentiation [88.88%(8/9), 88.88%(16/18)] were significantly higher than those in the group without lymph node metastasis and the group with high differentiation [42.85%(15/35), 26.92%(7/26)](all P<0.05). The expression levels of LYVE-1 in the group with lymph node metastasis and the group with medium-low differentiation [(13.31±6.23),(14.28±4.42)] was significantly higher than those in the group without lymph node metastasis and the group with high differentiation [(8.67±4.33),(6.39±2.09)](all P<0.05). The expressions of FoxC2 and LYVE-1 were not related to age, gender and tumor size(all P>0.05). The expression of FoxC2 was positively correlated with the expression of LYVE-1(r=0.55, P<0.01).Conclusions FoxC2 and LYVE-1 were involved in regulating the growth and lymph node metastasis of cutaneous squamous cell carcinoma.These results provide a new strategy for clinical diagnosis and treatment of cutaneous squamous cell carcinoma.