摘要
本文利用网络药理学和分子对接技术分析了热毒宁的保肝作用机制。筛选得到热毒宁50个有效成分,109个保肝作用潜在靶点。分子对接结果显示热毒宁的关键成分与保肝作用关键靶点具有较好的亲和力。热毒宁可能通过调控细胞凋亡和转录等生物过程,参与脂质和动脉粥样硬化、化学致癌受体活化、前列腺癌、流体剪切应力和动脉粥样硬化、乙型肝炎、AGE-RAGE信号通路等发挥保肝作用。热毒宁保肝作用体现了复方多成分、多靶点和多途径的特点,为深入研究热毒宁保肝作用机制提供了新的线索。
Network pharmacology and molecular docking technology were used to analyze the hepatoprotective mechanism of Reduning. Fifty active components of Reduning and 109 potential hepatoprotective targets were screened.The results of molecular docking showed that the key components of Reduning had good affinity with the key targets of liver protection. Reduning may regulated biological processes such as apoptosis and transcription, and it may play a hepatoprotective role by participating in lipid and atherosclerosis, activation of chemical carcinogenic receptors, prostate cancer, fluid shear stress and atherosclerosis, hepatitis B and AGE-RAGE signaling pathway. The hepatoprotective effect of Reduning embodies the characteristics of multi-component, multi-target and multi-channel of the compound.It provides new clues for the further study on the hepatoprotective mechanism of Reduning.
作者
柯佳群
余雪纯
赵梅玉
熊印华
Ke Jiaqun;Yu Xuechun;Zhao Meiyu;Xiong Yinhua(School of Pharmacy,Jiangxi Science and Technology Normal University,Nanchang 330013,Jiangxi,P.R.China)
出处
《江西科技师范大学学报》
2022年第6期82-88,共7页
Journal of Jiangxi Science & Technology Normal University
基金
国家自然科学基金(81660692)
江西省高等学校精细化学品工程技术研究中心开放课题(JFCEC-KF-2202)。
关键词
热毒宁
保肝作用
网络药理学
分子对接
靶点
通路
Reduning
hepatoprotective effect
network pharmacology
molecular docking
target
pathway
