摘要
目的:研究米索前列醇联合Bakri球囊宫腔填塞术对产后出血患者的影响。方法:回顾性选取2019年7月—2020年7月利川市民族中医院就诊的104例产后出血患者作为研究对象。根据治疗方式的不同将其分为对照组和研究组,各52例。对照组给予米索前列醇及宫腔内纱条填塞,研究组给予米索前列醇联合Bakri球囊宫腔填塞术。比较两组治疗前后Rho激酶(ROCK)、磷脂转运蛋白(phospholipid transfer protein,PLTP)水平、凝血指标、出血情况、不良情况、相关时间指标。结果:治疗后,两组ROCKⅠ、ROCKⅡ水平均高于治疗前,PLTP水平均低于治疗前(P<0.05),两组治疗后ROCKⅠ、ROCKⅡ、PLTP水平比较差异均无统计学意义(P>0.05)。治疗后,两组凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)均短于治疗前,纤维蛋白原(Fg)水平高于治疗前,研究组PT、TT、APTT短于对照组,Fg水平高于对照组(P<0.05)。术中,术后2、24 h,研究组患者出血量均少于对照组(P<0.05)。研究组产后感染、子宫切除、产后输血、子宫复旧不全发生率均低于对照组(P<0.05)。研究组手术操作时间、恶露持续时间、住院时间均短于对照组,月经恢复时间早于对照组(P<0.05)。结论:米索前列醇联合Bakri球囊宫腔填塞术止血效果良好,能改善产后出血患者ROCKⅠ、ROCKⅡ、PLTP水平,改善产妇凝血功能,减少术后出血量,促进产妇早日恢复。
Objective:To study the effect of Misoprostol combined with Bakri balloon uterine tamponade operation on patients with postpartum hemorrhage.Method:A total of 104 patients with postpartum hemorrhage who were treated in Lichuan National Traditional Chinese Medicine Hospital from July 2019 to July 2020 were retrospectively selected as the research objects.According to the different treatment methods,they were divided into control group and study group,52 cases in each group.The control group was given Misoprostol Tablets and intrauterine gauze tamponade,and the study group was given Misoprostol combined with Bakri balloon uterine tamponade operation.The levels of Rho kinase(ROCK)and phospholipid transfer protein(PLTP),coagulation indexes before and after treatment,bleeding condition,adverse conditions and related time indexes were compared between the two groups.Result:After treatment,the levels of ROCKⅠand ROCKⅡin the two groups were higher than those before treatment,and the level of PLTP was lower than that before treatment(P<0.05).There were no significant differences in the levels of ROCKⅠ,ROCKⅡand PLTP between the two groups after treatment(P>0.05).After treatment,the prothrombin time(PT),thrombin time(TT)and activated partial thromboplastin time(APTT)in the two groups were shorter than those before treatment,and the level of fibrinogen(Fg)was higher than that before treatment,the PT,TT and APTT in the study group were shorter than those in the control group,and the level of Fg was higher than that in the control group(P<0.05).During operation,2 h and 24 h after operation,the blood loss volume of patients in the study group was less than that in the control group(P<0.05).The incidences of postpartum infection,hysterectomy,postpartum blood transfusion and subinvolution of uterus in the study group was lower than those in the control group(P<0.05).The operation time,duration of lochia and hospital stay in the study group were shorter than those in the control group,and the recovery time of menstruation was earlier than that in the control group(P<0.05).Conclusion:Misoprostol combined with Bakri balloon uterine tamponade operation has good hemostatic effect,which can improve the levels of ROCKⅠ,ROCKⅡand PLTP in patients with postpartum hemorrhage,improve the coagulation function of puerpera,reduce the amount of bleeding after operation,and promote the early recovery of puerpera.
作者
田景鸣
裴家森
TIAN Jingming;PEI Jiasen(Lichuan National Traditional Chinese Medicine Hospital,Lichuan 445400,China;不详)
出处
《中外医学研究》
2023年第6期1-5,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
米索前列醇
止血球囊
产后出血
Misoprostol
Hemostatic balloon
Postpartum hemorrhage