高灵敏乙型肝炎病毒表面抗原和DNA检测的临床应用价值

Clinical value of highly sensitive hepatitis B virus surface antigen and DNA assays

慢性乙型肝炎抗病毒治疗适应证逐渐扩大,对各种程度治愈(部分治愈、功能性治愈、完全治愈)的追求不断提高,使得临床上对于提高乙型肝炎病毒表面抗原(HBsAg)和乙型肝炎病毒(HBV)DNA检测灵敏度的需求越来越迫切。该文从目前国内外高灵敏HBsAg和HBV DNA检测试剂的上市情况,及其在HBV感染诊断、抗病毒治疗适应证和治疗方案的选择、疗效预测和停药指导、疗效判定和疾病结局的预测等方面的应用,指出高灵敏检测技术在慢性HBV感染治疗的全程管理中具有重要作用。

For patients with chronic hepatitis B,the indications of antiviral treatment are gradually expanding,and the pursuit of various degrees of cure(partial cure,functional cure and complete cure)is consistently improving,which enhances the urgent clinical need for improving the detection sensitivity of hepatitis B virus(HBV)surface antigen and DNA.Based on the availability of commercial highly sensitive hepatitis B surface antigen and HBV DNA detection reagents,we summarized their applications in the diagnosis of HBV infection,their role on guiding selection of antiviral treatment agents and treatment plans,their prediction efficacy and indication for drug withdrawal,their role on monitoring therapy efficacy and the prediction of disease outcomes.Taken together,highly sensitive hepatitis B virus surface antigen and DNA assays and related detection technology play an important role in the whole management process of chronic HBV infection.