聚乳酸载萘普生微球形貌控制

Fabricating the Morphology of Naproxen-Loaded Polylactic Acid Microspheres

用静电喷雾技术制备了聚乳酸/萘普生(PLA/NPX)复合微球,用扫描电子显微镜(SEM)观察微观形貌,研究了NPX添加量、溶剂种类、电压和针头内径对微球形貌影响。结果表明,当NPX添加量小于20%、电压为18 kV、针头直径为0.6 mm、接收距离为15 cm、溶剂为二氯甲烷时,微球的分散较为均匀,随着NPX含量的增加,导致颗粒粘附、团聚;二氯甲烷中添加乙醇导致微球表面凹陷,微球平均粒径由5.18μm降低至2.41μm;增加电压使得复合微球平均粒径减小,且电压过大增加微球形貌不规则程度;针头内径降低至0.25 mm,复合微球平均粒径由5.18μm降低至3.8μm,平均粒径显著降低。

The polylactic acid/naproxen(PLA/NPX)composite microspheres were prepared by electrostatic spray technology,and the microscopic morphology was observed by scanning electron microscope(SEM).The influence of NPX addition amount,solvent type,voltage and needle diameter on the microsphere morphology was studied.The results show that when the amount of NPX added does not exceed 20%,the voltage is 18 kV,the receiving distance is 15 cm,and the solvent is dichloromethane,uniformly distributed microspheres can be obtained,which further increases the NPX content,resulting in particle adhesion and agglomeration.The addition of ethanol to methane resulted in the surface indentation of the microspheres,and the average particle size of the composite microspheres was reduced from 5.18 to 2.41μm.The average particle size of the composite microspheres decreased with the increase of voltage,and excessive voltage increased the degree of irregularity of the morphology of microspheres.The inner diameter of the needle was reduced to 0.25 mm,the average particle size of the composite microspheres was reduced from 5.18 to 3.8μm,and the average particle size was significantly reduced.