沈阳市74例获得性免疫缺陷综合征患者眼底病变的临床特征分析

Clinical features of fundus lesions of 74 patients with acquired immunodeficiency syndrome in Shenyang

目的:探讨沈阳市获得性免疫缺陷综合征(AIDS)患者眼底病变的特点、影响因素及与CD4^(+)T细胞计数的关系。方法:回顾性病例研究。选取2021-01/12期间就诊于辽宁电力中心医院的AIDS患者74例,分析患者的眼底表现及外周血CD4^(+)T细胞计数情况。结果:纳入AIDS患者眼底病变检出率为58%。眼底病变患者外周血CD4^(+)T细胞计数明显低于正常眼底患者[29(6,55)/μL vs 76(35,103)/μL,P<0.01]。外周血CD4^(+)T细胞计数≤50/μL的患者眼底病变患病率最高(74%)。Logistic回归分析显示,随着CD4^(+)T细胞计数的增多,发生眼底病变的几率降低(OR=0.977,95%CI 0.964~0.991,P<0.01)。结论:AIDS患者眼底病变与外周血CD4^(+)T细胞有关,外周血CD4^(+)T细胞计数降低是AIDS患者发生眼底病变的危险因素,对AIDS患者应常规进行眼底检查,有利于眼底病变的早期发现。

·AIM:To investigate the clinical features and factors of fundus lesions in patients with acquired immunodeficiency syndrome(AIDS) in Shenyang and the relationship between fundus lesions and CD4^(+)T cell count.·METHODS:Retrospective case study.A total of 74 cases with AIDS who were treated in the Central Hospital of Liaoning Electric Power Supply Co.,Ltd.,from January 2021 to December 2021 were selected.The fundus manifestation and CD4^(+)T cell count of the patients were analyzed.·RESULTS:The total detection rate of fundus lesions in AIDS patients was 58%.CD4^(+)T cell count in the patients with fundus lesions was significantly lower than that in the patients with normal fundus [29(6,55)/μL vs.76(35,103)/μL,P<0.01].The rate of fundus lesions was the highest in the patients with CD4^(+)T cell count ≤ 50/μL(74%).Logistic regression analysis showed that as the CD4^(+)T cell count increased,the incidence of fundus lesions decreased(OR=0.977,95%CI 0.964~0.991,P<0.01).·CONCLUSION:Fundus lesions in AIDS patients related to CD4^(+)T cell count.Decreasing CD4^(+)T cell count was a risk factor of fundus lesions for AIDS patients.Routine fundus examination is important for the early diagnosis of fundus lesions in AIDS patients.