血清胰岛素样生长因子-1、白细胞介素-12与子痫前期患者不良妊娠结局的相关性

Correlation between serum insulin-like growth factors, interleukin-12 and adverse pregnancy outcomes in patients with preeclampsia

目的 探讨子痫前期(PE)患者胰岛素样生长因子-1(IGF-1)、白细胞介素-12(IL-12)水平情况,并分析两指标与患者不良妊娠结局的关系。方法 选择医院2019年10月—2021年10月的200例PE患者,随访至PE患者分娩,记录其临床结局;同时于产妇PE确诊时,检测其血清IGF、IL-12水平,询问并记录患者基线资料;观察血清IGF、IL-12水平与PE患者不良妊娠结局的相关性,并分析血清IGF、IL-12水平预测PE患者不良妊娠结局的临床价值。结果 随访至分娩,200例PE患者中62例妊娠结局不良,占31.00%;不良组病情重度高于良好组,血清IGF-1水平低于良好组,IL-12水平高于良好组,差异有统计学意义(P<0.05);logistic回归分析检验,血清IGF-1低表达、IL-12过表达、病情重度与PE患者不良妊娠结局有关(P<0.05);绘制受试者工作特征(ROC)曲线结果显示,血清IGF-1、IL-12水平单独及联合预测PE患者不良妊娠结局的AUC分别为0.849、0.767、0.927,均有一定价值,且联合预测的价值更高。结论 血清IGF低表达、IL-12过表达与PE患者不良妊娠结局有关,且血清IGF、IL-12水平可预测PE患者不良妊娠结局的发生风险。

Objective This paper aims to investigate the levels of insulin-like growth factor-1(IGF-1) and interleukin-12(IL-12) in patients with preeclampsia(PE) and to analyze the relationship between the two indexes and adverse pregnancy outcomes. Methods A total of 200 patients with PE in the hospital from October 2019 to October 2021 were selected and followed up until delivery, and their clinical outcomes were recorded;meanwhile, their serum levels of IGF and IL-12 were detected when PE was diagnosed, and the baseline data of patients were inquired and recorded;the correlation between serum IGF and IL-12 levels and adverse pregnancy outcomes in patients with PE was observed, and the clinical value of serum IGF and IL-12 levels in predicting adverse pregnancy outcomes in patients with PE was analyzed. Results From follow-up to delivery, 62 of the 200 patients with PE had poor pregnancy outcome, accounting for 31.00%;compared with the good group, the severity of the disease in the adverse group was higher than that in the good group, the serum IGF-1 level was lower than that in the good group, and the IL-12 level was higher than that in the good group, with the differences of statistical significance(P<0.05);logistic regression analysis test showed that the low expression of serum IGF-1, the overexpression of IL-12 and the severity of the disease were related to the adverse pregnancy outcome of PE patients(P<0.05);the receiver operating characteristic(ROC) curve was drawn, and the results showed that the AUCs of serum IGF-1 and IL-12 alone and combined to predict adverse pregnancy outcomes in PE patients were 0.849, 0.767 and 0.927, respectively, all had certain value, and the value of combined prediction was higher. Conclusion Low expression of serum IGF and overexpression of IL-12 are related to adverse pregnancy outcomes in patients with PE, and the levels of serum IGF and IL-12 can predict the risk of adverse pregnancy outcomes in patients with PE.