血糖浓度、胱抑素C联合24h尿蛋白检测在诊断糖尿病合并肾功能衰竭中的应用效果分析

Analysis of the application effect of blood glucose concentration,cystatin C combined with 24h urine protein detection in the diagnosis of diabetes mellitus complicated with renal failure

目的 分析糖尿病合并肾功能衰竭诊断中血糖、胱抑素C、24 h尿蛋白联合检测的应用效果。方法 回顾性选取2020年2月—2022年2月本院糖尿病患者100例,依据合并肾功能衰竭情况分为合并组、未合并组3组,各50例。另选取同期本院健康体检人员50例作为健康对照组,统计分析3组人员的血糖、Cys-C、24 h UmALB水平、阳性情况,并统计分析合并组不同肾功能衰竭程度患者的血糖、Cys-C、24 h UmALB水平、阳性情况,统计分析合并组血糖、Cys-C、24 h UmALB单独与联合检测的阳性情况。结果 合并组、未合并组患者的FBG、HbA_(1c)、Cys-C、24 h UmALB水平均高于健康对照组(P<0.05),合并组患者的FBG、HbA_(1c)、Cys-C、24 h UmALB水平均高于未合并组(P<0.05)。合并组、未合并组患者的FBG、HbA_(1c)、Cys-C、24 h UmALB阳性率均高于健康对照组(P<0.05),合并组患者的FBG、HbA_(1c)、Cys-C、24 h UmALB阳性率均高于未合并组(P<0.05)。合并组轻度、中度、重度肾功能衰竭患者的FBG、HbA_(1c)、Cys-C、24 h UmALB水平均逐渐升高(P<0.05)。合并组轻度、中度、重度肾功能衰竭患者的FBG、HbA_(1c)、Cys-C、24 h UmALB阳性率均逐渐升高(P<0.05)。合并组FBG、HbA_(1c)、Cys-C、24 h UmALB联合检测的阳性率高于单独检测(P<0.05)。结论 糖尿病合并肾功能衰竭诊断中血糖、胱抑素C、24 h尿蛋白联合检测的应用效果较单独检测好。

Objective This paper aims to analyze the application effect of combined detection of blood glucose, cystatin C and 24 h urine protein in the diagnosis of diabetes mellitus complicated with renal failure. Methods A total of 100 patients with diabetes mellitus in our hospital from February 2020 to February 2022 were retrospectively selected, and they were divided into three groups, the combined group and the uncombined group, according to the complicated renal failure, with 50 cases in each group. In addition, 50 health examinees in our hospital during the same period were selected as the control group. The blood glucose, Cys-C, 24 h UmALB levels and positive situation of the 3 groups were analyzed statistically, and the blood glucose, Cys-C, 24 h UmALB levels and positive situation of the patients with different renal failure degrees in the combined group were analyzed statistically, and the positive situation of the blood glucose, Cys-C, 24 h UmALB alone and combined tests were analyzed statistically. Results The levels of FBG, HbA_(1c), Cys-C and 24 h UmALB in the combined group and the uncombined group were higher than those in the control group(P<0.05), and the levels of FBG, HbA_(1c), Cys-C and 24 h UmALB in the combined group were higher in the uncombined group(P<0.05). The positive rates of FBG, HbA_(1c), Cys-C and 24 h UmALB in the combined group and uncombined group were higher than those in the control group(P<0.05), and the positive rates of FBG, HbA_(1c), Cys-C and 24 h UmALB in the combined group were higher in the uncombined group(P<0.05). The levels of FBG, HbA_(1c), Cys-C and 24 h UmALB in patients with mild, moderate and severe renal failure in the combined group were gradually increased(P<0.05). The positive rates of FBG, HbA_(1c), Cys-C and 24 h UmALB in patients with mild, moderate and severe renal failure in the combined group were gradually increased(P<0.05). The positive rate of combined detection of FBG, HbA_(1c), Cys-C and 24 h UmALB in the combined group was higher than that of single detection(P<0.05). Conclusion The combined detection of blood glucose, cystatin C and 24 h urine protein in the diagnosis of diabetes mellitus with renal failure is better than single detection.