摘要
胶质瘤发病率高、预后差,其发病机制是相关领域的研究热点及难点。近年来研究发现,N6-甲基腺嘌呤(m6A)与胶质瘤的发生发展密切相关,m6A过程中相关蛋白在胶质瘤的形成中发挥着重要作用,是潜在的胶质瘤治疗靶点。本文围绕m6A相关蛋白上游调控机制进行综述,以期进一步明确m6A相关蛋白作为胶质瘤诊断标志物及潜在治疗靶点的应用前景。
Glioma has high incidence and poor prognosis.Glioma pathogenesis is the research hotspot and difficulty in related fields.N6-methyladenin(m6A)is closely related to glioma development,and m6A related proteins play important roles in glioma,which is a potential therapeutic target for glioma.In this paper,the upstream regulatory mechanism of m6A related proteins is reviewed,and the prospect of m6A related proteins as diagnostic markers and potential therapeutic targets for glioma is discussed.
作者
秦屹
张威
黄河
张颖
杨志倩
Qin Yi;Zhang Wei;Huang He;Zhang Ying;Yang Zhiqian(Department of Neurosurgery,First Affiliated Hospital of Guangdong Pharmaceutical University,Guangdong Engineering and Technology Research Center of Stem Cell Therapy for Pituitary Diseases,Guangzhou 510080,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2023年第1期77-83,共7页
Chinese Journal of Neuromedicine
基金
广东省医学科学技术研究基金(A2020419)
广州市科技计划项目(202102021067)。
