抗突触蛋白-3α抗体相关脑炎的研究进展

Recent advance in anti-neurexin-3αantibody-associated encephalitis

突触蛋白-3α是2016年发现的一种可导致自身免疫性脑炎的新型抗体。抗突触蛋白-3α抗体相关脑炎患者一般伴有感染前驱症状或情绪改变,临床表现主要为癫痫发作、记忆障碍、意识模糊或昏迷、中枢性通气不足、异常行为和言语障碍等。笔者现围绕近年来该病的发病机制、诊断及鉴别诊断、治疗、预后等方面的国内外研究进展进行综述,以期拓展临床医生对该病的认识。

Neurexin-3α,discovered in 2016,is a new type of autoimmune encephalitis antibody.Anti-neurexin-3αantibody-associated encephalitis is generally associated with prodromal symptoms or mood changes,having main clinical manifestations as seizures,memory disorders,confusion or loss of consciousness,central ventilation insufficiency,abnormal behavior,and speech disorders.This paper reviews the relevant research progress at home and abroad about pathogenesis,diagnosis and differential diagnosis,treatment and prognosis of anti-neurexin-3αantibody-associated encephalitis,so as to expand the understanding of clinicians for this disease.