角膜共聚焦显微镜在神经系统疾病中的应用研究进展

Recent advance in corneal confocal microscopy for neurological diseases

角膜共聚焦显微镜(CCM)是一种无创精准、简单、快速的可视化活体角膜分析技术,可直接对角膜神经纤维进行实时采集及定量分析。研究显示,CCM可应用于中枢神经系统退行性疾病、脱髓鞘疾病、变性疾病等多种类型病变的诊断与预后评估。本文现围绕上述内容的研究进展进行总结与综述,以期为神经系统疾病的诊断及预后/严重程度评估提供新思路。

Corneal confocal microscopy(CCM)is a non-invasive,simple and rapid visual corneal imaging technique,which can directly conduct real-time collection and quantitative analysis of corneal nerve fibers.Studies have shown that CCM can be used in the diagnosis and prognosis evaluation of degenerative diseases,demyelinating diseases,degenerative diseases and other types of diseases of the central nervous system.In this paper,the recent advance in CCM in neurological diseases is summarized to provide new ideas for their diagnosis and prognosis evaluation.