移植供肺的保存与功能维护

Preservation and functional maintenance of lung allograft

肺移植作为终末期肺病最后的治疗手段,不仅可以明显延长患者的生存时间,还能很大程度改善患者的生活质量。在过去的几十年里,随着外科技术、免疫抑制药和移植术后管理方面的进步,全球肺移植手术量激增。但供肺短缺极大限制了肺移植的发展,需要开发创新方法来扩大供者库。捐献者数量以及潜在供肺的有效保存与功能维护是扩大供者库的关键,供肺质量是保证肺移植受者术后长期生存的重要前提,移植肺的保存与功能维护在保证供肺质量方面尤为重要。本文总结了获取前供肺的管理与维护、供肺获取及移植肺的保存与功能维护的最新进展,以期为临床肺移植的发展提供参考。

As the final resolution for end-stage lung disease,lung transplantation can not only significantly prolong the survival,but also remarkably improve the quality of life of recipients.In recent decades,with the advancement of surgical techniques,immunosuppressants and post-transplantation management,the quantity of lung transplantation has been surged around the globe.However,the shortage of donor lung has severely restricted the development of lung transplantation.It is necessary to develop innovative approaches to expand the donor pool.The number of donors and effective preservation and functional maintenance of potential donor lungs play a key role in expanding the donor pool.The quality of donor lung is a critical precondition to ensure the long-term survival of lung transplant recipients.Preservation and functional maintenance of donor lung are of significance for guaranteeing the quality of lung allograft.In this article,research progresses on the management and maintenance of donor lung before procurement,the procurement of donor lung and the preservation and functional maintenance of lung allograft were reviewed,aiming to provide reference for the development of lung transplantation in clinical practice.