铁基纳米材料在肿瘤化学动力学治疗中的研究进展

Research Progress of Iron-based Nanomaterials in Tumor Chemodynamic Therapy

化学动力学疗法(chemodynamic therapy, CDT)是一种由活性氧(reactive oxygen species, ROS)介导,借助肿瘤微环境(tumor microenviroment, TME)特性在肿瘤原位发生Fenton或类Fenton反应生成羟基自由基·OH,诱导肿瘤细胞损伤和凋亡的治疗方法.铁基材料最早应用于CDT,对近些年应用于CDT的铁基材料进行综述,简述了目前铁基纳米材料在临床上的发展状况并详细论述了3类铁基纳米材料:晶体铁纳米材料、非晶体铁纳米材料、铁基金属有机框架纳米材料在肿瘤治疗上的应用,旨在为铁基纳米材料在肿瘤CDT上的进一步研究提供参考.

Chemodynamic therapy(CDT) is a therapeutic approach mediated by reactive oxygen species(ROS) that induces tumor cell damage and apoptosis by generating hydroxyl radicals in tumor in situ with the help of tumor microenvironment(TME) properties by Fenton or Fenton-like reactions.Fe-based materials were first used in CDT.In this paper, the Fe-based materials used in CDT in recent years were reviewed.The current clinical development of Fe-based nanomaterials were briefly introduced, and the application of three Fe-based nanomaterials, including crystalline Fe-based nanomaterials, amorphous Fe-based nanomaterials and Fe-based organic framework nanomaterials, in tumor therapy were discussed in detail, aiming to provide reference for further research of Fe-based nanomaterials on tumor CDT.