5Esteller M. Epigenetics in cancer [J]. N Engl J Med, 2008, 358 (11) : 1148 -1159.
6Ogawa O, Eccles MR, Szeto J, et al. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour [ J ]. Nature, 1993, 362(6422) : 749 -751.
7Eden A, Gaudet F, Waghmare A, et al. Chromosomal instability and tumors promoted by DNA hypomethylation [ J ]. Science, 2003, 300(5618) : 455.
8Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor- suppressor gene by DNA methylation in renal carcinoma [ J ]. Proc Natl Acad Sci USA, 1994, 91(21) : 9700 -9704.
9Merlo A, Herman JG, Mao L, et al. 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor pl6/CDKN2/MTS1 in human cancers [ J]. Nat Med, 1995, 1 ( 7 ) : 686 - 692.
10Graft JR, Gabrielson E, Fujii H, et al. Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic,heterogeneous loss of E-cadherin expression during metastatic pro- gression [J]. J Biol Chem, 2000, 275(4): 2727-2732.