標準三聯療法一線治療幽門螺桿菌的根除率回顧性分析

A retrospective study on the eradication rate of the standard triple therapy as first-line treatment for H.pylori infection

目的評估標準三聯療法一線治療幽門螺桿菌的根除率。方法回顧性分析2016年1月~12月本院標準三聯療法一線根治幽門螺桿菌並複查的成人連續患者,分別紀錄其一般情況、根除方案及根除療效。結果共103例患者納入研究,91例根除成功,總體根除率為88.3%。接受amoxicillin或metronidazole的患者分別為100例和3例,amoxicillin組的根除率顯著高於metronidazole組(91.0%對0%,P=0.001)。接受esomeprazole、rabeprazole、pantoprazole、dexlansoprazole或omeprazole的患者依次為87、7、5、3、1例,不同PPI組的根除率差異無統計學意義(P=0.073)。結論PPI+clarithromycin+amoxicillin的三聯方案根除率良好,PPI+clarithromycin+metronidazole的三聯方案根除率低,不同PPI對於標準三聯方案根除率的影響無統計學意義。

Objective To assess the eradication rate of the standard triple therapy as first-line treatment for H.pylori infection.Methods H.pylori infected patients who received the standard triple therapy and confirmed the eradiation from January and December of 2016 in Kiang Wu Hospital were recorded.Their clinical characters were analyzed.Results A total of 103 patients were recruited.H.pylori eradication was achieved in 91 of 103(88.3%)patients.The number of patients treated with amoxicillin and metronidazole were 100 and 3 respectively.Amoxicillin group showed higher eradication rate than metronidazole group(91.0%VS 0%,P=0.001).The number of patients treated with esomeprazole,rabeprazole,pantoprazole,dexlansoprazole and omeprazole were 87,7,5,3,1respectively.No significant differences were found between different PPI groups(P=0.073).Conclusion PPI-clarithromycin-amoxicillin triple therapy showed acceptable eradication rate,whereas PPI-clarithromycin-metronidazole triple therapy showed lower eradication rate.No significant differences were found between different PPI groups.