脑铁沉积动物模型的研究进展

Research progress on animal models of brain iron deposition

铁是大脑中最丰富的金属元素,铁稳态是保证大脑发挥正常生理功能的基础。当脑内铁代谢紊乱引起铁沉积,过量的铁会促进自由基的形成和氧化应激,从而导致神经元死亡。为充分研究脑铁沉积疾病,需要建立动物模型。本文就不同建模方式及其实验鼠品种、铁剂种类进行综述,为脑铁沉积模型建立提供参考。

Iron is the most abundant metal element in the brain,and iron homeostasis ensures normal physiological functions occur in this organ.When iron metabolism is disrupted in the brain,excess iron promotes the formation of free radicals and oxidative stress,leading to neuronal death.To fully study cerebral iron deposition diseases,animal models need to be established.This article reviews different modeling method,experimental mouse species,and iron types,and provides a reference for the establishment of brain iron deposition models.