Fibroscan在慢性乙型肝炎肝纖維化診斷中的應用價值

The significance of using fibroscan in the diagnosis of liver stiffness in chronic hepatitis B.

目的探討Fibroscan在慢性乙型肝炎患者中的臨床應用價值。方法應用Fibroscan對364例慢性乙型肝炎患者進行檢測,同時測定HBeAg、HBV DNA、ALT、AST、AFP、GGT、ALB及PLT,比較肝纖維化程度與各種生化指標之間的關係。結果肝硬度在男性患者、年齡≦35與>55歲組間比較、ALT水平在1~2xULN及2~5xULN與≦0.5xULN比較等均有明顯組間差別(P<0.05),並且在HBV DNA水平及各生化指標有明顯差異(P<0.05);在肝纖維化比較中性別及HBeAg在F2與F4有明顯組間差別(P<0.05)。結論Fibroscan可作爲監測慢性乙型肝炎肝纖維化程度的一種無創性診斷,爲臨床診治提供依據。

Objective To investigate the clinical usage of fibroscan among chronic hepatits B patients.Methods Fibroscan was performed in 364 chronic hepatitis B patients for measuring liver stiffness.HBeAg,HBV DNA,ALT,AST,AFP,GGT,ALB and PLT levels were also detected at the same time.The comparison between liver stiffness and biochemical indexes was measured.Results There was statistical significant(P<0.05)between liver stiffness among male patients,age group≦35 and>55,ALT levels within 1-2 ULN and 2-5xULN compared with≦0.5xULN,HBV DNA levels and all biochemical indexes.The liver fibrosis level in HBeAg among F2 and F4 level had statistical significant(P<0.05).Conclusion Fibroscan can be used as a non-invasive diagnosis method for monitoring the progression of liver stiffness in chronic hepatitis B.