惡性黑色素瘤11例臨床病理分析

Study on Clinicopathological analysis of 11 malignant melanoma

目的探討惡性黑色瘤的臨床特點,病理學特點,診斷及鑒別診斷。方法對本院2008年以收治的11例惡性黑色瘤進行臨床資料統計,應用HE染色,免疫組化等方法進行病理學特徵觀察。結果11例惡性黑色素瘤患者中,男3例,女8例,男:女為1:2.67;發病年齡9歲~83歲,平均44.5歲;位於足部3例,位於背部2例,手臂1例,腰部1例,臀部1例,小腿1例,1例,唇黏膜1例;免疫組化顯示所有病例HMB45,Melan-A陽性,10例S-100陽性,Ki-67增生指數約10%~40%。結論惡性黑色素瘤惡性程度高,轉移性強,發展迅速,預後差,診斷惡性黑色素瘤依靠臨床症狀及病理特點,惡性黑色素瘤以手術為主,手術切除範圍及輔助治療方案應根據臨床分期。

Objective To analyze the clinical characteristics,pathological features,diagnosis and differential diagnosis of melanoma and latest development in clinical treatment.Methods From 2008 to 2015,11 cases of melanoma were collected and analyzed with HE and Immunohistochemical staining.Results Of the 11 cases of melanoma,3 were males and 8 were females,with the male to female ratio=1:2.67.The age of onset was between 9 to 83 years old,and the mean age was 44.5 years old.Three cases were located on the foot,2 on the back,1 on the arm,1 on the waist,1 on the hip,1 on the leg,and 1 on the lip mucosa.Immunohistochemical study showed positive staining for HMB45.and Melan-A.10 cases express S-100.The Ki-67 was between 10%-40%.Conclusion Melanoma is highly aggressive,and progress rapidly.It can easily develop metastasis and has poor prognosis.Melanoma can be diagnosed by clinical symptoms and pathological features.Surgery is the primary treatment.The surgical excision area of melanoma and the used adjunctive therapy are dependent on clinical stage.