肺非小細胞癌手術和靶向治療後微小肺腦膜上皮樣結節持續存在1例報告

Minute pulmonary meningothelial-like nodules are not eliminated after resection and targeted therapy of non-small cell lung cancer:A case report

To date,due to increasing use of high-resolution computed tomography(CT)scans,more and more cases of minute pulmonary meningothelial-like nodules(MPMNs)were reported[1,2].Clinicopathological and histological characteristics of this lesion have also been well described.The lesion appears as multiple nodules on CT image,and mainly observed in the patients,especially female,with malignant pulmonary tumors,such as adenocarcinoma of the lung[2].Histologically,MPMNs are comprised of arachnoid-like cells similar meningothelial cell in meningioma in the H&E slice.Recently,large pulmonary meningothelial-like nodule was reported[3].Here we report a case of MPMNs,which presented diffusely as multiple nodules in the lung field and some admixed with adenocarcinoma.Three year follow-up examinations by low-dose helical computed tomography scan after surgical partial resection of the cancer demonstrate that the MPMN lesions in the rest lung are not eliminated after targeted therapy of the lung cancer.