毛囊瘤4例臨床病理特征及文獻複習

Clinicopathologic features of 4 cases of trichofolliculoma and literature review

目的對4例毛囊瘤的臨床病理分析及文獻複習。方法4例毛囊瘤採用常規HE染色,並分析其臨床病史及病理學特點。結果3例(75%)6個月內就診,男女之比為1:3,本病主要病理表現為病變位於真皮內,邊界清楚,中央可見一個擴張的毛囊,腔內可見角質物、毛幹,擴張的毛囊外可見次級毛囊及皮脂腺,鄰近可見結締組織鞘圍繞。結論毛囊瘤是向毛囊發育的一種良性腫瘤,是一種少見的錯構瘤,多見於18歲~49歲的男性患者,多見於頭面部,特別以鼻翼兩側及頭皮毛囊分佈區域多見,本病可採用手術切除、激光或冷凍,治療方法根據腫瘤的部位及數目而定,單發者首選手術切除。

Objective To evaluate the clinicopathologic features of trichofolliculoma and review of the literatures.Methods Four cases of trichofolliculoma were investigated by hematoxylin-eosin.The clinical history and pathologic features were analyzed.Results Three cases(75%)revisited the doctor within 6 months.Male:female=1:3.The main presentation of pathology is the lesion located in dermis and has clear margin.One dilated hair follicle is seen in the center and contains keratin and hair shaft fragments.Emanating from the dilated hair follicle are numerous small secondary hair follicles and sebaceous glands.Connective tissue sheath surrounding the dilated hair follicle is also seen.Conclusion Tichofolliculoma is a uncommon benign tumor of hair follicle differentiation and harmartoma that usually appear in 18-49 year old male,often arises on head and face,especially in both side of ala nasi and scalp where the hair follicle distribution.The operation resection,laser or frozen are choices of therapy.Therapy depended on the number and the site of the tumor.The operation resection is first choice of single lesion.