腦膠質母細胞瘤6例臨床病理分析

Study on clinicopathological analysis of 6 glioblastoma

目的探討膠質母細胞瘤的臨床特點、病理學特點、診斷及鑒別診斷,進一步為臨床治療提供有效的參照。方法對本院2008年以收治的6例膠質母細胞瘤進行臨床資料統計、應用HE染色、免疫組化等方法進行病理學特徵觀察。結果位於大腦5例,位於小腦1例,手術後復發1例,位於大腦主要表現為頭暈、視物模糊、嘔吐、失語、乏力、癲癇發作等,病變位於小腦主要為行走不穩、乏力、頭暈;免疫組化顯示GFAP、vimentin、P53陽性、Ki-67高表達。結論膠質母細胞瘤來源於星形細胞,組織形態具有一定的特徵、惡性程度高、進展快、易復發。

Objective To analyze the clinical characteristics,pathlogical features,diagnosis and differential diagnosis of glioblastoma and provide effective references for clinical treatment.Methods During the period from 2008 to 2014,6 cases of glioblastoma were collected and analyzed with HE and immunohistochemical staining.Results The brain were 5 cases,the cerebellum was 1 case.Relapse was 1 case.The tumor site of occurrence influenced the patients’main symptoms.The clinical symptoms of the cases were dizziness,bluring of vision,vomiting,aphasia,tiredness,seizures in cerebral hemispheres and walk unsteadily,vomiting,dizziness in the cerebellum.Immunohistochemical study showed positive staining for GFAP,vimintin,P63.The Ki-67 was highly expressed.Conclusion This tumor origins from astrocyte and has marked pathological features.The malignant degree of glioblastoma is very high,its progression is rapid,and it is easy to relapse.