异种蛋白诱导法建立IgA肾病动物模型研究进展

Research progress on establishment of animal model of IgA nephropathy by heterogeneous protein induction

本文总结了目前常见的异种蛋白诱导法建立IgA肾病(IgAN)动物模型的各种造模方法,指出其各自的特色与不足及各模型间的异同点,并提出了模型改良思路,以期为建立更加安全、稳定、成功率高、可重复性强、且与人类更为相似的IgAN动物模型提供思路。

This paper summarizes various methods for establishing animal models of IgA nephropathy(IgAN)by immune induction.The models’respective characteristics and shortcomings and the similarities and differences between them are discussed.We propose that improvements to models are needed and provide ideas for establishing safer,more stable animal models with a higher success rate and robust repeatability that more closely mimic human IgAN.