焦虑和抑郁导致偏头痛患者fALFF改变:一项fMRI横断面研究

Anxiety and depression lead to fALFF changes in migraine patients: an fMRI cross-sectional study

目的 探讨焦虑抑郁对偏头痛患者脑功能改变的影响。方法 采用静息态功能磁共振成像数据,分析46例无先兆偏头痛患者和34例年龄和性别匹配的健康对照者的分数低频振幅(fALFF)变化。并采用Pearson相关分析来探索fALFF变化与临床特征之间的关系。结果 偏头痛患者,有无焦虑抑郁,左侧小脑后叶的fALFF值均升高。无焦虑抑郁偏头痛患者,丘脑、颞叶和额叶fALFF值下降。伴有焦虑抑郁偏头痛患者的小脑fALFF值与蒙特利尔认知评估量表评分呈负相关。结论 左侧小脑后叶是偏头痛患者中一个持续激活的脑区。该区可能是进一步了解偏头痛发作机制的目标脑区。

Objective To investigate the effects of anxiety and depression on brain functional alterations in migraine patients.Methods Resting-state functional magnetic resonance imaging data were used to analyze the changes in fractional amplitude of low-frequency fluctuation (fALFF) in 46 patients with migraine without aura and 34 age-and gender-matched healthy controls.Pearson correlation analysis was used to explore the relationship between changes in fALFF and clinical characteristics.Results The fALFF value of the posterior lobe of left cerebellum increased in migraine patients with or without anxiety and depression.In patients with migraine without anxiety and depression,decreased fALFF values were found in the thalamus,temporal lobe,and frontal lobe.In patients with migraine with anxiety and depression,fALFF value in cerebellum was negatively correlated with the Montreal Cognitive Assessment scores.Conclusion The posterior lobe of left cerebellum is a continuously activated region in migraine patients.This region may be a target region for further understanding the mechanism of migraine attack.